Bioinformatics Scientist (Remote)

Job DescriptionJob DescriptionXenoSTART, the preclinical division of START is a translational research organization focused on creating relevant preclinical cancer models. Our xenograft models represent each cancer type and disease stage and are established from patients at our domestic and international cancer centers. The XenoSTART Patient-Derived Xenograft (XPDX) platform includes over 2,500 models annotated with each donor patient’s cancer treatment and outcome data and characterized using IHC, DNA/RNA sequencing, and relevant in vivo drug efficacy.
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​Our XPDX models are clinically annotated and include patient treatment history and outcome and are characterized through genomic profiling, histologic analysis, and in vivo drug sensitivity to relevant standards of care. These models may be utilized in the following manner:

• In vivo PK/PD and efficacy studies
• In vivo efficacy panel screens (indication or target focused)
• In licensing of models for internal studies
• Custom model development
• Orthotopic and radiotherapy studies
• Ex vivo and organoid studies

We are hiring a Bioinformatics Scientist to perform data analysis and integration across various domains (high-throughput transcriptomic and genomic data),and applies best-in-class algorithms or develops new algorithms that directly address the motivating biological and clinical questions. This position will also effectively present complex results in a clear and concise manner that is accessible to a diverse audience including physicians, scientists, and lay staff.

This is a remote role. The annual base salary for this role is $115,000 - $135,000. However, base pay may vary depending on multiple individualized factors including market location, job-related knowledge, skills, and experience.

Essential Responsibilities

• Develop bioinformatics data processing tools and workflows to analyze omics data to support sponsors and internal clients.
• Develop and run secondary analysis pipelines for DNA and RNA-Seq in AWS for human xenograft samples.
• Organize sequence data files and results in a manner consistent with best practices. Work with web developers to facilitate transfer of data to the XenoSTART catalogue.
• Organize, facilitate and document transfer of requested data to sponsors, including NGS files and analysis results.
• Analyze and annotate human xenograft samples for driver genes, pathogenic variants, and cohort characteristics.
• Performs other duties as assigned.

Education & Experience

• MS degree or equivalent Computational/Informatics experience with 5+ years of applied experience in Pharma/Biotech or academic setting focused on oncology.

Education and Experience:

• PhD degree or equivalent Computational/Informatics experience with 3+ years of applied experience in Pharma/Biotech or academic setting focused on oncology.
• Hands-on experience in processing and analyzing NGS data (DNA & RNA-Seq) using common bioinformatics pipelines and with AWS.
• Ability to collaborate and apply leading algorithms from academic and industry, creative and practical use of systems biology methods in oncology-based gene/target discovery, interpretation of cellular processes, and biomarker discovery.
• Knowledge of genetics, immunology, tumor immunology and / or tumor biology is a plus.
• Proficient in data visualization and communication with a multi-disciplinary team.

Best-in-Class Benefits and Perks
We value our employees’ time and efforts. Our commitment to your success is enhanced by a competitive compensation, depending on experience, and an extensive benefits package including:

• Comprehensive health coverage: Medical, dental, and vision insurance provided
• Robust retirement planning: 401(k) plan available with employer matching
• Financial security: Life and insurance for added protection
• Flexible financial options: Health savings and flexible spending accounts offered
• Well-being and work-life balance: Paid time off, flexible schedule, and remote work choices provided
• Plus, we work to maintain the best environment for our employees, where people can learn and grow with the company. We strive to provide a collaborative, creative environment where everyone feels encouraged to contribute to our processes, decisions, planning, and culture.

More about The START Center for Cancer Research
Deeply rooted in community oncology centers globally, The START Center for Cancer Research provides access to specialized preclinical and early-phase clinical trials of novel anti-cancer agents. START clinical trial sites have conducted more than a thousand early-phase clinical trials, including for 43 therapies that were approved by the FDA. START represents the world’s largest roster of Principal Investigators (PIs) across its eight clinical trial sites. Committed to accelerating passage from trials to treatments, START delivers hope to patients, families, and physicians around the world. Learn more at STARTresearch.com.

Ready to be part of a team changing the future of cancer treatment?
Join us in our mission to conquer cancer, one clinical trial at a time. Your expertise and dedication can help us bring hope and healing to patients worldwide. Please submit your application online.

We are an equal opportunity employer that welcomes and encourages in the workplace. We do not discriminate on the basis of , , , marital status, , , ancestry, physical or mental , medical condition, , genetic information, , , or expression, veteran status, or any other status protected under federal, state, or local law.