Cell & Systems Biology Staff Scientist

Job DescriptionJob Description

Title: Cell & Systems Biology Staff Scientist

Location: on site, Frederick, MD

Status: Full Time

Travel: 5-10%

Salary Range: $65,000-$110,000

Position Summary:

USAMRIID, located at Fort Detrick, Maryland, works closely with other U.S. Army Medical Research and Development Command (USAMRDC) organizations, Department of Defense (DoD), the Interagency (including Interagency Laboratories), and private companies to accomplish its mission of protecting the Warfighter from biological threats and being prepared to investigate disease outbreaks or threats to public health. This includes conducting Research, Development, Testing, & Evaluation (RDTE) of medical countermeasure against biological threats and the safety, quality assurance, project management, and core support required for these research activities.

The Molecular Biology Division works to combat biological threats and weapons of mass destruction by developing high-throughput sequencing and protein profiling to identify emerging pathogens. It also evaluates and improves medical countermeasures, follows the DoD's roadmap for their development, and ensures their ethical use, including FDA approval. The Division also explores expanding indications and combinations with existing countermeasures.

The Cell & Systems Biology Staff Scientist will conduct basic and systems biology research on current and emerging threats at BSL-2 and coordinate efforts with staff to evaluate BSL-3 and BSL-4 pathogens, in support of the BD and infectious disease program for the Therapeutics Discovery (TD) Branch. The Scientist will directly perform experimental research and provide support in a range of biochemical, cell biological, immunological, systems biology and standardization of assays towards therapeutics development. Position contingent upon contract award.

Duties/Responsibilities:

• Generate various reporter based functional assays and evaluate pathogens as well as small molecule library using the reporter assay. Use multi-array technologies such as opera high-content imaging, flow cytometry, real time pcr, cytokine assays using meso scale discovery's (msd) and biochemical assays (immunoprecipitation/western blot) to further characterize the mechanism of action of the therapeutics. The support analysis of high throughput data using spotfire and genedata. Then participate in characterization of suitable lead compound for broad spectrum use against multiple bio-threat
• Conduct research directed towards developing an integrated multi-omics (genomics, transcriptomics and proteomics) approach to design and test various pathogens in vitro and/or in vivo, carry out analysis of large datasets using data mining tools such as ingenuity, nextbio, metascape, cytoscape, and use the data set to extract key features, regulatory networks and identify host correlates related to infectious disease. This information shall guide the therapeutic discovery
• Perform various assays including functional genomic screens and proteomic studies to identify novel host factors that modulate the innate immune signaling pathways to bacterial biothreat pathogens such as Anthracis, burkholderia mallei and b. Pseudomallei and viral pathogens such as filoviruses and alphaviruses.
• Maintain an orderly laboratory environment in compliance with regulations. Coordinate ordering of supplies to support research efforts with division staff. Assist in training new personnel including students and other technicians and mentoring junior
• Communicate experimental data, laboratory or other work-related issues to the appropriate poc. and with vendors for technical support and troubleshooting laboratory equipment within their assigned
• Assist in the preparation of technical reports and standard operating procedures, write manuscripts and if required, present research findings at one scientific conference per In collaboration with USAMRIID leadership, author or coauthor research proposals, solicitations, and other vehicles to solicit financial support to meet USAMRIID mission/portfolio objectives. This includes answering service calls from government sponsors (e.g. DTRA).
• Assist in the preparation of technical reports, standard operating procedures, and manuscripts relating to their research efforts. Present results in written and oral format publicly and internally as

Minimum Requirements:

• Masters degree or higher in molecular biology or related field
• 3+ years of experience in innate immunology
• Experience in BSL-2 laboratory or higher
• Experience using systems biology to study host-pathogen interactors
• Experience carrying out analysis of large OMIC datasets
• Must be eligible to enroll in the BPRP and CS-PRP Programs
• Active BPRP and/or CS-PRP status
• Must be able to obtain/maintain a Secret clearance
• Active Secret clearance

Work Environment:

• Laboratory environment

Physical Demands:

• May lift up to 25lbs

Benefits:

KIC offers a comprehensive benefits package to eligible full-time employees including: Medical, Dental, and Vision Insurance, 401k with Match, Life and ADD Coverage, Short and Long Term , Paid Time Off and Holidays, Education Assistance/Tuition Reimbursement, Employee Assistance Program, Employee Discount Program, and more!

Apply online at our website: https://kikiktagruk.applicantpool.com/

Disclaimer:

This is not to be an exclusive list of all responsibilities, duties, and skills required of the person in this job. KIC is an Equal Opportunity Employer. KIC considers all applicants for employment without regard to , , , , religion, , physical or mental , family responsibility, marital status, , political affiliation, veteran's status, , or any other legal protected status.

Please view Equal Employment Opportunity Posters provided by OFCCP here (http://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm).

Pursuant to The Alaska Claims Settlement Act 43 U.S.C. Sec. 1601 et seq., and federal contractual requirements, Kikiktagruk Inupiat Corporation, may legally grant certain preference in employment opportunities to KIC Shareholders, and their Descendants.

Successful candidates must adhere to KIC's Drug and Alcohol policy/testing requirements and may be required to pass a background and/or Motor Vehicle Records check.

The salary range for this position is based on several factors, including relevant experience, education, skills, and current market conditions. We aim to provide a fair and equitable salary, that remains competitive within the industry.