Principal Research Scientist, I

Job DescriptionJob DescriptionCompany Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

AbbVie is looking for talented Protein Biochemists with strong Protein Sciences expertise to join our team at our headquarters in the Chicago area. This exciting role is central to advancing small molecule drug discovery across a variety of disease areas using innovative biochemical strategies. As an integral member of our team, you will drive projects and collaborate across functions to develop robust and scalable protein workflows and address strategic questions in support of key drug discovery activities, including assay development, screening, structure-based design, and exploratory biology.
Success in this position requires a solid foundation and proven track record in Protein biochemistry and related fields, good understanding and applications of computational protein design tools, and strong collaborative skills.

Key Responsibilities:

• Innovate and lead experimental plans to address essential questions about protein functions and overcome challenges in generating protein /protein complexes with low yield, aggregation issues.
• Enhance and implement best practices in protein expression, purification, and characterization to support drug discovery programs.
• Design complex protein constructs and guide purification processes to enable cutting-edge biochemical/biophysical assays and structural biology research.
• Serve as the technical expert in protein production, utilizing advanced chromatographic techniques on AKTA systems.
• Effectively use of advanced computational tools and the development of novel approaches to strengthen our program capabilities.
• Work closely with project teams to identify and solve key questions within the domain of protein biochemistry.
• Stay ahead of scientific discoveries to integrate valuable insights into evolving protein engineering strategies.
• Lead cross-functional teams, driving biochemistry-focused initiatives that enhance program success.

Qualifications

• Ph.D. in Biochemistry, Biophysics, Bioinformatics, or a related field, with 6+ years of relevant experience.
• Proven expertise in producing high-quality proteins and addressing challenges with complex context.
• Proficiency in programming and the application of comprehensive bioinformatics tools, and computational biology technologies would be a plus.
• A deep understanding of best practices in the field of membrane protein would be beneficial.
• Excellent organizational and time-management skills, coupled with an independent and detail-oriented approach to problem-solving.
• Strong project management skills, with the ability to lead and contribute to multiple simultaneous projects.
• Outstanding collaborative and communication skills, adaptable to both computational and non-computational scientific audiences.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
• This job is eligible to participate in our short-term incentive programs. ​
• This job is eligible to participate in our long-term incentive programs. ​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing and .  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of , , , , , (including ), physical or mental disability, medical condition, genetic information, or expression, , marital status, status as a protected veteran, or any other legally protected group status.

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